Nitric oxide is an essential gas in your body that helps improve the amount of blood flow to your muscle tissues (1).

We’re back with new and improved “2022 friendly” rankings for the best nitric oxide supplements out there.

Nitric oxide supplements are more popular than ever, helping people pump out longer workouts in the gym, run more miles without fatigue, and improve performance in sport athletes.

Nitric oxide supplements, often called NO boosters, go hand-in-hand with creatine supplements.

The list below ranks the best nitric oxide supplements on the market, according to product quality, customer reviews, and pricing. After the rankings, we broke down exactly what nitric oxide supplements are and how they work.

So what’s the best nitric oxide supplement on the market?

And the winner is…

1 – Cellucor NO3 Chrome


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One of the most potent NO supplements on the market, NO3 Chrome is our #1 recommended nitric oxide supplement.

The Cellucor company has been around for a while, and NO3 Chrome has established itself as a top dog in the pre-workout space.

Premium quality and potent ingredients for advanced users – not for beginners.

Cellucor NO3 was awarded the best NO supplement for a reason. It’s one of the most effective nitric oxide supplements, using the potent ingredient arginine nitrate (which helps your body perform every time you exercise).

Aside from having nitric oxide precursors, it also has antioxidants and other performance-enhancing ingredients like citrulline malate and nitrosigine (2). One of the best selling nitric oxide supplements on both Amazon and, and they boast incredible customer reviews across the internet.

It’s not the cheapest nitric oxide on the market, but if you are looking for the best performance NO supplement on the market, Cellucor NO3 Chrome won’t disappoint.

2 – Pro Supps NO3 Drive


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 This popular Nitric Oxide supplement also has Astralagus Root and Ginseng combined with the L-Citrulline to boost nitric oxide levels in the body.

Additionally, Agmatine Sulfate is also used to stimulate the nitric oxide production. The combination of these work together and provide added drive to your lifestyle, whether you are a bodybuilder, runner, hiker, swimmer, or enjoy any other physical hobbies (3).

Each bottle has about 90 capsules and every dose contains the powerful antioxidant, Resveratrol, also found in raspberry ketones.

Not only are they a best-seller on Amazon, Pro Supps NO3 Drive is also becoming a favorite among beginner and intermediate level weight lifters and bodybuilders.

3 – Evlution Nutrition ENGN


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One of the best tasting and most potent NO supps on the market, ENGN Mind-to-Muscle Matrix Proprietary Blend gets you jacked.

This particular supplement contains Creatine Monohydrate, Bete Alanine and other crucial bodybuilding ingredients.

It has a little bit of Caffeine Anhydrous and Huperzine A to help stimulate cognitive functions in your brain, good for improving your focus and memory.

It also comes in a variety of different flavors so that you can choose one you like.

Aside from being top rated nitric oxide supplement on popular shopping outlets such as Amazon, Evlution Nutrition ENGN is one of our top choices for the remarkable quality of the product and the reputation they have created for their brand  (4).

4 – BSN Nitrix 2.0


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One of the best selling NO supplements on Amazon, BSN Nitrix 2.0 has become one of the most popular brands on the market.

It has three forms of creatine, tons of antioxidants and even black pepper extract, making it one of the best nitric oxide supplements on the market, according to product quality and pricing.

It helps with stimulating the nitric oxide production in your body using L-Citrulline.

This supplement also contains grape seed extract and resveratrol, both potent antioxidants (like camu camu berries and chamomile flowers).

The black pepper extract is used in nutrient and mineral absorption in the blood and even stimulates blood flow throughout the body as well (5).

5 – Muscletech Neurocore


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Not your simple NO boosting supplement here. This supplement not only enhances bodybuilding exercises, but also helps stimulate your brain and improves hormonal functions.

It uses natural herbal extracts, and when combined together, proves to be effective in boosting nitric oxide levels throughout the body.

It also contains L-Citrulline and arginine AKG to act as the precursor for the nitric oxide production.

Muscletech Neurocore even has Beta Alanine to increase endurance and strength during gym workouts.

On top of this, it has 120 mg of caffeine and 50 mg of L-Theanine per serving, and creatine monohydrate and rhodiola root to give you the best boost a legal workout supplement can offer (6).

Not the cheapest NO supplement, but you get a lot of great extras.

How do nitric oxide supplements work?

Nitric oxide is a molecule used to deliver messages between cells in the body. 

It performs different functions in the body like regulating blood circulation, and helping with regular activities in the vital organs like your stomach, kidneys, liver, brains and lungs (7).

They help in transmitting information in between brain cells, they help the immune system fight off bacteria and defend against tumors and infections, reduce inflammation, improve sleeping patterns, regulate blood pressure, assist in gastric motility, increase sense recognition like sense of smell, and even elevate your levels of endurance and strength (8).

One of its oxides is nitrogen.  It is a free radical and physiologically works by relaxing the vascular smooth muscles and binds to the heme moiety of the cytosolic guanylate cyclase where it eventually leads to vasodilation. It can be used as a supplement or a simple inhaling gas, depending on the structure of the compound (9).

Many NO supplements contain the amino acid arginine, or the arginine alpha-ketoglutarate. It boosts the nitric oxide levels and in turn helps increase muscle growth, improving strength and muscle performance.

Research indicates that increasing levels of nitric oxide in the body along with of the arginine supplements increases blood vessels and improves blood flow, and even improves the endothelial lining of blood vessels. This mechanism has also shown to improve exercise performance in many patients with cardiovascular problems.  

The list of nitric oxide benefits goes on and on, from increasing muscle nutrient delivery to increasing the rate of protein synthesis (10). This is why many supplement stores have a hard time keeping the best brands of nitric oxide supplements in-stock. 

Athletes and bodybuilders like taking NO supplements with L-arginine and L-citrulline to help facilitate the blood and oxygen flow into the skeletal muscles.

The combination of these also helps in the removal of exercise-induced lactic acid, which is a major factor in fatigue and recovery time.  Nitric oxide supplements reduce this buildup and dramatically decrease recovery times after your workout (11).

What are the side effects of nitric oxide?

Nitric oxide supplements rarely have side effects in the body, although they rarely can affect the heart, cause erectile dysfunction and even tamper with muscle building.

For heart disease, NO actually offers a lot of benefits. The interior surface or the endothelium of the arteries produce nitric oxide. Over time, plaque can buildup in the arteries.

When this occurs it reduces the body’s capability to produce nitric oxide. NO supplements can help increase this production, so there’s no real surprise they are becoming more popular than ever. 

For men with erectile dysfunction, most NO supplements boost the nitric oxide pathway in the body to cascade the enzyme reactions to help produce more blood flow into the male genital organ causing better erections (12). No one likes to talk about it, but if you’re experiencing ED, you might want to give a NO supplement a try (or try a natural test booster).

When it comes to Nitric Oxide supplements for body builders, many use it to help intensify their workout routines.

 It wont pump up the muscles, meaning it does not add or produce nitric oxide which is a gas, but most supplements have L-arginine and can increase the nitric oxide levels in the body. This will then increase the blood flow to the muscles and other organs.

Clinical studies have been conducted and have showed that with these supplements over time, there is no real significant increase in muscle size and fullness, however they have increased the intensity of exercise and endurance among elderly people and athletes.

NO supplements have also been found to be helpful to people with cardiovascular problems like atherosclerosis and angina pectoris (13).

If you are interested in buying a nitric oxide supplement, check out our rankings above and choose the best fit for you. Whether it be affordability or quality of product, the rankings will simplify the decision for you.

The HealthRanks Team

The HealthRanks Team is composed of like-minded health experts who share a passion for sharing their health knowledge for the benefit of others. Check out our about page for more information.


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